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| First Round Draft Pick History |
| 1 | 2 | 2 | 2021 | Annual Draft | P | Devin | Williams | MLB |
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| Complete Draft History |
| 2 | 15 | 35 | 2022 | Annual Draft | SS | Edmundo | Sosa | MLB |
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| 3 | 1 | 41 | 2022 | Annual Draft | P | Zach | Thompson | MLB |
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| 3 | 15 | 55 | 2022 | Annual Draft | OF | LaMonte | Wade | MLB |
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| 4 | 15 | 75 | 2022 | Annual Draft | 3B | Matt | Duffy | MLB |
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| 5 | 15 | 95 | 2022 | Annual Draft | P | Craig | Stammen | MLB |
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| 6 | 15 | 115 | 2022 | Annual Draft | C | Tomas | Nido | MLB |
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| 7 | 15 | 135 | 2022 | Annual Draft | 2B | Jace | Peterson | MLB |
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| 8 | 15 | 155 | 2022 | Annual Draft | C | Yermin | Mercedes | MLB |
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| 1 | 2 | 2 | 2021 | Annual Draft | P | Devin | Williams | MLB |
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| 3 | 8 | 48 | 2021 | Annual Draft | C | Andrew | Knapp | MLB |
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| 3 | 10 | 50 | 2021 | Annual Draft | C | Kyle | Higashioka | MLB |
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| 5 | 8 | 88 | 2021 | Annual Draft | P | Trevor | Cahill | MLB |
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| 5 | 10 | 90 | 2021 | Annual Draft | P | Eric | Yardley | MLB |
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| 7 | 10 | 130 | 2021 | Annual Draft | 1B | Daniel | Vogelbach | MLB |
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| 7 | 20 | 140 | 2021 | Annual Draft | P | Anthony | Misiewicz | MLB |
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