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| First Round Draft Pick History |
| 1 | 4 | 4 | 2021 | Annual Draft | P | Ian | Anderson | MLB |
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| Complete Draft History |
| 1 | 4 | 4 | 2021 | Annual Draft | P | Ian | Anderson | MLB |
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| 2 | 4 | 24 | 2021 | Annual Draft | SS | Andres | Gimenez | MLB |
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| 2 | 18 | 38 | 2021 | Annual Draft | OF | Leody | Taveras | MLB |
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| 3 | 4 | 44 | 2021 | Annual Draft | P | Garrett | Crochet | MLB |
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| 4 | 4 | 64 | 2021 | Annual Draft | P | Codi | Heuer | MLB |
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| 5 | 4 | 84 | 2021 | Annual Draft | P | Ryan | Sherriff | MLB |
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| 6 | 4 | 104 | 2021 | Annual Draft | P | Jake | McGee | MLB |
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| 7 | 4 | 124 | 2021 | Annual Draft | P | Cody | Ponce | MLB |
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| 8 | 4 | 144 | 2021 | Annual Draft | C+ | Erik | Kratz | MLB |
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